Reliance Life Sciences operates state-of-the-art
facilities in the life sciences domain.
The
flagship facility is the Dhirubhai Ambani
Life Sciences Centre (DALC) in Navi Mumbai
spread over 20 acres. DALC is among the
most diverse and integrated life sciences
campuses in the world. Its diversity stems
from the wide spectrum of areas of research
and development undertaken and its integration
comes from repository, laboratory research,
pre-clinical research, clinical research
and manufacturing facilities; all located
in the same campus.
The second facility is in Bangalore,
for clinical pharmacology and clinical
data management.
Research
The Dhirubhai Ambani Life Sciences Centre
houses research labs over 120,000 sq ft
of space and has the following laboratories:
- Molecular Biology
- Microbiology
- Enzymology
- Virology
- Animal Cell Culture
- Molecular Medicine
- Genetics
- Microscopy
- Cytology
- Protein Chemistry
- Fermentation
- Downstream Separation
- Protein Purification
- Histopathology
- Pathology
- Bioanalysis
- Plant Tissue Culture
- Plant Metabolic Engineering
- Phytochemistry
- Synthetic Chemistry and Process Development
- Medicinal Chemistry
- Analytical Chemistry
- Radio Immunoassay
- Instrumentation
These labs are supported by on-campus
utility systems for power, water, HVAC
and gases.
Cord Blood Repository
Reliance
Life Sciences has established South Asia's
first, most advanced and completely automated
stem cell enriched umbilical cord blood
repository. This is the first cord blood
repository in the world to be accorded
a licence by an official regulatory authority,
Food and Drug Administration (FDA), Government
of India.
Animal House
Reliance Life Sciences has established
a state-of-the-art, barrier-maintained
Animal Facility for breeding and experimentation
on small animals to meet internal, as
well as client needs.
The facility breeds and maintains animals in individual ventilated cages (IVC)
and conforms to the guidelines outlined
by the Committee for the Purpose of Control
and Supervision of Experiments on Animals
(CPCSEA).
It is the only facility in India designed
to carry out experiments on immuno-compromised
animals in a class 10,000 facility.
cGMP Manufacturing
Plant 1 manufacturing facility of Reliance
Life Sciences is located in Mumbai and
is designed for manufacture of clinical
lots and initial market introduction of
plasma proteins and recombinant therapeutic
proteins. This facility complies with
cGMP guidelines, operates under licence
from Indian FDA and is WHO-GMP certified.
Plant 2 manufacturing facility for commercial
manufacture of recombinant proteins, as
well as cell-based therapies, is located
in Navi Mumbai. This facility has suites
both for mammalian cell culture and microbial
fermentation, and is EMEA approved. It
incorporates state-of-the-art distributed
control systems.
Plant 3 manufacturing facility for kilo-scale
manufacture of pharmaceutical APIs is
located in Navi Mumbai and is designed
to comply with EMEA and USFDA guidelines.
Plant 4 manufacturing facility for commercial
scale manufacture of plasma proteins is
located in Navi Mumbai and is designed
to comply with EMEA and USFDA guidelines.
Plant 5 manufacturing facility for biopolymers
and biochemicals for medical applications.
Integral to Plant 1, 2 and 4 are separate
fill-finish suites with high speed lines
for vials and pre-filled syringes
Cell Processing
Reliance Life Sciences has three cGMP
cell processing suites in operation in
Mumbai to meet clinical trials for cell-based
therapies and initial market introduction.
Eight more cGMP cell processing suites
are operational at Plant 2 located at
the Dhirubhai Ambani Life Sciences Centre.
Quality Control
Reliance Life Sciences has quality control laboratories located at the Dhirubhai
Ambani Life Sciences Centre, Navi Mumbai
and at the first cGMP facility in Mumbai.
These laboratories are state-of-the-art
facilities and include stability chambers
and microbiology suites.
Clinical Pharmacology
Reliance Life Sciences operates a three-clinic, 111 bed Phase
I and Bioavailability/ Bioequivalence
facility at the Dhirubhai Ambani Life
Sciences Centre, Navi Mumbai and an 80-bed
wireless telemetry equipped facility at
Bangalore. These facilities are supported
by in-house pathology and bioanalytical
facilities.
Assisted Reproduction Clinic
Reliance Life Sciences operates an Assisted Reproduction, Endoscopy and Fetal
Medicine clinic under the name of ReGenesis
at Worli, Mumbai. The Centre has facilities
for
- Advanced Infertility Management:
- Intra Uterine Insemination (IUI)
- In Vitro Fertilization (IVF)
- Intra Cytoplasmic Sperm Injection (ICSI)
- Sperm Retrieval Procedures like PESA, MESA, TESA, and TESE
- Laser Assisted Hatching (LAH)
- Pre-implantation Genetic Diagnosis (PGD)
- Donor Oocyte Programme
- Gamete Cryopreservation and Sperm Banking
- Gynecological Endoscopy
- Diagnostic and Operative Laparoscopy and Hysteroscopy
- Fertility Enhancing Endoscopic Surgery
- Fetal Medicine
- Early Fetal Assessment
- Anomaly Scanning
- Intrauterine Diagnostic and Therapeutic Procedures
- Clinic for Recurrent Pregnancy Loss
Plant Tissue Culture
Reliance
Life Sciences operates a state-of-the-art
plant tissue culture facility at the Dhirubhai
Ambani Life Sciences Centre, Navi Mumbai.
It has a total production capacity of
five million plants per annum, with a
total production area of 30,000 square
feet. The facility holds five growth rooms
with temperature and humidity control
and three separate inoculation rooms to
avoid cross contamination.
Green House
Reliance Life Sciences has greenhouses (6,000 square feet) located at DALC,
which are fitted with fan and pad systems
and foggers to control and maintain temperature
and humidity. A Shade House (3,000 square
feet) is used for secondary hardening
of in-vitro plants. There are seven hardening
centres across various states in Andhra
Pradesh, Gujarat, Maharashtra, Tamil Nadu,
and Uttar Pradesh. There is a separate
green house for transgenic plants.
Agronomy
Reliance Life Sciences has three R&D farms, primarily for research work
on biodiesel crops and for plantation
of tissue cultured crops under different
agro-climatic conditions. These are located
at Kakinada in Andhra Pradesh, Nagothane
in Maharashtra and Gandhar in Gujarat.
