Reliance Life Sciences – Reliance Group

Patents

Reliance Life Sciences is actively engaged in building a strong and diversified Intellectual Property portfolio in pharmaceuticals and biotechnology. So far, Reliance Life Sciences has filed over 360 patents at national and international levels covering the entire spectrum of its research and development activities

Reliance Life Sciences believes that the broad nature of its intellectual property provides several opportunities for product development, partnering and licensing.

Selected Publications

Year 2009
  • RNAi mediated knockdown of AURKB and EGFR shows enhanced therapeutic efficacy in prostate tumor regression. Gene Therapy online publication 3 December (2009).
  • Clinical grade mesenchymal stem cells transdifferentiated under xenofree conditions alleviates motor deficiencies in a rat model of Parkinson's disease Cell Biology International (2009)
  • Formulation and In vitro Evaluation of Transdermal Delivery of Zidovudine- An Anti-HIV Drug Journal of Applied Polymer Science, (2009)
  • Prevalence and Geographic Distribution of Hepatitis C Virus Genotypes in Indian Patient Cohort Infection, Genetics and Evolution, Available online from 11 April (2009)
  • Downregulation of Inflammatory Responses by Novel Caffeic Acid Ester Derivative by Inhibiting NF-kappa B Journal of Clinical Immunology (2009), (29), pp. 90 - 98
  • Novel caffeic acid ester derivative induces apoptosis by expressing fasl and downregulating NF-KappaB: Potentiation of cell death mediated by chemotherapeutic agents. Journal of cellular physiology. (2009) Mar;218(3):653-62.
  • A dihydrobenzofuram lignan induces cell death by modulating mitochondrial pathway and G2/M cell cycle and arrest Journal of Medicinal chemistry April (2009)
  • Polymeric scaffolds for tissue engineering: an overview, Biotechnology Emerging Trends, edited by R Z Sayyed and A S Patil, Scientific publisher, Jodhpur, India, pp 415-448 (2009).
  • TP53 codon 72 polymorphism and cervical cancer: pooled analyisis of individual data of 15834 women from 49 studies. The Lancet Oncology (2009)
  • Genotype Distribution in Cervical Cancer in India: Results from a Multi-center Study. Asian Pac J Cancer Prev (2009)
  • Occurrence of vivipary in Jatropha curcas Current Science (2009)
  • India's first public cord blood repository - looking back and moving Forward Indian Journal of Hematology & Blood Transfusion, (2009), Volume 25, 111-117
Year 2008


  • High-frequency plant regeneration from leaf-disc cultures of Jatropha curcas L.: an important biodiesel plant. Plant Biotechnology. Rep. 2, 7-11 (2008)
  • Lactic acid production by Lactobacillus delbrueckii in a dual reactor system using packed bed biofilm reactor Letters in Applied Microbiology Volume 46 Issue 6, Pages 661 - 666
  • Developments in polymeric devices for oral insulin delivery. Expert opinion on Drug Delivery Expert Opinion on Drug Delivery, April (2008), Vol. 5, No. 4, Pages 403-415. (2008)
  • Nano/micro technologies for delivering macromolecular therapeutics using 3 poly(D,L-lactide-co-glycolide) and its derivatives. Journal of Controlled Release 125: 193-209
  • An efficient process for production and purification of hyaluronic acid from Streptococcus equi subsp. zooepidemicus. Biotechnology Letters 30: 493-496
  • Three-dimensional organization of dermal fibroblasts by macromass culture. Biotechnol Appl Biochem 49(Pt 1 ):65-72
  • Microencapsulation of Doxycycline into Poly(lactide-co-glycolide) by Spray Drying Technique: Effect of Polymer Molecular Weight on Process Parameters. J. Appl. Polymer Sci. Volume 108 Issue 6, Pages 4038 - 4046 (2008)
  • Cultured Melanocytes: From skin biopsy to transplantation Cell Transplantation (2008);17(3):351-60. (2008)
  • One year survival and significant reversal of motor deficits in parkinsonian rats transplanted with hESC derived dopaminergic neurons. Biochem Biophys Res Commun. 373(2):258-64 (2008)
  • Stem cells for the treatment of neurological disorders. CNS Neurol Disord Drug Targets. (2008); 7(1):98-109.
  • Assessment of drug induced developmental toxicity using human embryonic stem cells Cell Biology International Volume 32, Issue 11, November (2008), Pages 1412- 1424
Year 2007
  • Cell cycle regulation in maintaining immortality of embryonic stem cells, J Stem Cells, (2007); 2(3): 159-66.
  • 8-Methyl-4-(3-diethylaminopropylamino) pyrimido [4',5';4,5] thieno (2,3-b) quinoline (MDPTQ), a quinoline derivate that causes ROS-mediated apoptosis in leukemia cell lines. Toxicology and Applied Pharmacology (2007)
  • A panel of tests to standardize the characterization of human embryonic stem cells March (2007), Vol. 2, No. 2, Pages 179-192 doi:10.2217/17460751.2.2.179)
  • Modulating fertility outcome in assisted reproduction technologies by the use of dydrogesterone. Gynaecological Endocrinology 23(S1): 68-72 (2007)
  • Solvent Detergent Treated Plasma: Safer Tool in the Hands of Transfusionists Indian Journal of Hematology and Blood Transfusion Vol 33 /1 - 2, Pgs 32 - 35 (2007)
  • Human Umbilical Cord Blood Serum can replace foetal bovine serum in the culture of mesenchymal stem cells Cell Biology International, 31293-298 (2007)
  • Similar pattern in cardiac differentiation of human embryonic stem cell lines, BG01V and ReliCell™ hES1 under low serum concentration supplemented with BMP-2. Differentiation. 75(2):112-122, February (2007)
  • Generation and transplantation of dopaminergic neurons from Embryonic stem cells. Current Stem Cell Research & Therapy (2007), 2(2), 139-147
  • Heart Development : The Battle between Mesoderm and Endoderm Stem Cells and Development (2007) 16 (1), 3-6
Year 2006
  • Enriched NCAM positive cells form functional dopaminergic neurons in the rat model of Parkinson's disease. Stem Cells Dev Stem Cells and Development. August (2006), 15(4): 575- 582 (2006)
  • Human embryonic stem cells have a unique epigenetic signature. Genome Research Genome Res. Sep; 16(9):1075-83. (2006)
  • Assessment of pluripotency and multi-lineage differentiation potential of NTERA-2 cells as a model for studying human embryonic stem cells. Cell Prolif. Dec; 39(6):585-98 (2006)
  • Functional hepatocyte-like cells derived from mouse embryonic stem cells. A novel in vitro hepatotoxicity model for drug screening. Toxicity in vitro (20): 1014-1022 (2006)
  • Characterisation and in vitro differentiation potential of a new embryonic stem cell line, ReliCell hES1. Differentiation 74(2-3):81-90 (2006)
  • A Smad- and Wnt-dependent pathway in embryonic cardiac development. Stem Cells Dev 15(1): 129-139 (2006).
  • Establishment, Characterization and differentiation of human embryonic stem cells into three germ layers. Chapter in book Human embryonic stem cells, Nova publications pp. 65-93 (2006)
Year 2005
  • Role of hepatocyte-like cells in differentiation of cardiomyocytes from mouse embryonic stem cells. Stem Cells Dev 14(2): 153-161 (2005)
  • The trans-differentiation potential of limbal fibroblast cells. Dev Brain Res 160(2): 239-251 (2005)